(2-Isothiocyanatoethyl)dimethylamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

HRID 2163877Notes

Reaction equation

HRID 2163877 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][N:16]=[C:17]=[S:18]>>[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][NH:16][C:17]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[S:18]

Participants

3

Reactant 2

HCID 3853726(2-Isothiocyanatoethyl)dimethylamineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 20557883N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

Procedure

Treating N-(2-pyrimidylmethyl)ethylenediamine with 2-dimethylaminoethyl isothiocyanate, then concentrating and separating by column chromatography by the procedure of Example 40(a)(ii) gives the title compound.

Workup

  1. concentrationconcentrating
  2. customseparating by column chromatography by the procedure of Example 40(a)(ii)

Sources & evidence

ORD record
ord-467f770eba534598b6a6d53139ac273c
Source dataset
uspto-grants-1979_01
Patent number
US04137234

Reaction notes

Loading…