Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

HRID 2163878Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Product 1

HCID 20557893N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

Procedure

Reacting N-(2-pyrazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-0ec546a81a6645bc9666ad3dd8286bc4
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137234

Reaction notes

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