Methyl Isocyanate → N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

HRID 2163882Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[N:2]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 21698444N-(3-pyridazinylmethyl)ethylenediamine

Product 1

HCID 20557601N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

Procedure

Reacting N-(3-pyridazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-e2fcac667cbc4589be0687d4a34124de
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137234

Reaction notes

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