Ethylenediamine → HCID 178484973, compound

HRID 2163969Notes

Reaction equation

HRID 2163969 reaction equation
ClC[C:3]1[N:8]=[CH:7]C=[CH:5][N:4]=1.C(N)C[NH2:11].[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[CH2:19][NH:20][CH2:21][CH2:22][NH2:23].CN=C=S>>[C:5]([NH:4][C:3]([NH:8][CH3:7])=[N:23][CH2:22][CH2:21][NH:20][CH2:19][C:14]1[N:15]=[CH:16][CH:17]=[CH:18][N:13]=1)#[N:11]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 11167Methyl isothiocyanateHCID 128773712-(Chloromethyl)pyrimidineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 178484973HCID 178484973, compound

Procedure

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Example 3(b) to give the title compound.

Workup

  1. customgives
  2. concentrationafter concentrating
  3. customThis thiourea is reacted with lead cyanamide by the procedure of Example 3(b)

Sources & evidence

ORD record
ord-15b369f7e95c4fd9935313f5c2204bd2
Source dataset
uspto-grants-1979_01
Patent number
US04137237

Reaction notes

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