Ethylenediamine → HCID 178484974, compound

HRID 2164008Notes

Reaction equation

HRID 2164008 reaction equation
C(N)CN.[S:5]1[CH:9]=[CH:8][N:7]=[C:6]1[CH2:10][NH:11][CH2:12][CH2:13][NH2:14].[C:15]([NH:17][C:18](=[N:21][CH3:22])SC)#[N:16]>>[C:15]([NH:17][C:18]([NH:21][CH3:22])=[N:14][CH2:13][CH2:12][NH:11][CH2:10][C:6]1[S:5][CH:9]=[CH:8][N:7]=1)#[N:16]

Participants

4

Reactant 3

HCID 3301EthylenediamineHCID 1111031-Cyano-2,3-dimethylisothioureaHCID 17944882N-(2-thiazolylmethyl)ethylenediamine

Product 1

HCID 178484974HCID 178484974, compound

Procedure

Reacting ethylenediamine with 2-chloromethylthizaole by the procedure of Example 34, then reacting the resulting N-(2-thiazolylmethyl)ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(a), gives N-cyano-N'-methyl-N"-[2-(2-thiazolylmethylamino)ethyl]guanidine. Hydrolysis of this compound by the procedure of Example 3(e) gives N-methyl-N' -[2-(2-thiazolylmethylamino)ethyl]guanidine trihydrochloride.

Sources & evidence

ORD record
ord-8190ac8212034453b0dec26bfe3c9871
Source dataset
uspto-grants-1979_01
Patent number
US04137237

Reaction notes

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