N-bromobutanimide → HCID 178520386, compound

Participants

Reaction Steps

N-Bromosuccinimide (95 mg, 0.53 mmol) was added to a solution of 1,1-difluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol (200 mg, 0.53 mmol) in acetonitrile (5 mL) at ambient temperature. After stirring for 1 hr, the reaction mixture was concentrated in vacuo. Chromatography over silica eluting with 0-100% ethyl acetate/hexane afforded 3-(5-bromo-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)-1,1-difluoro-2-[4-(1H-pyrazol-1-yl)phenyl]propan-2-ol as an orange solid.

Provenance & Evidence