Ammonia → HCID 22750110, compound

Participants

Reaction Conditions

Reaction Steps

A stream of ammonia is passed into a solution of 4-ethoxy-10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline (5 g) in pyridine (200 cc) until the solution is saturated. The solution obtained is then stirred at a temperature of about 20° C. for 16 hours. The resulting suspension of red crystals is poured into iced water (600 cc). The crystalline precipitate is filtered off and then washed successively with water (5 × 10 cc), ethanol (3 × 10 cc) and then diethyl ether (2 × 20 cc). After drying under reduced pressure (1 mm Hg) at 25° C., 4-amino-10-nitro-7-oxo-7H-indolizino[7,6,5-de]-isoquinoline (4.18 g) is obtained in the form of orange-red crystals.

Provenance & Evidence