Potassium Carbonate → 1-[6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one-2-yl]-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	Benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine	HCID 200274	—
Reactant	2-(3-Chloropropyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-one	HCID 13327027	—
Reactant	Chloroform methanol	HCID 21584188	—
Solvent	Chlorobenzene	HCID 7964	—
Product	1-[6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one-2-yl]-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane	HCID 22750119	—

Reaction Steps

1-[6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one-2-yl]-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane was prepared analogous to Example 1 (b) by reacting 1-(6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one-2-yl)-3-chloropropane with N-(3,4-dimethoxy-phenylethyl)-N-benzyl-amine in chlorobenzene in the presence of potassium carbonate. Yield: 2.2 gm (69.8% of theory); Rf -value (chloroform/methanol = 19:1): 0.8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04137318
Source dataset	uspto-grants-1979_01
ORD ID	ord-f41b305cbcd346338a00ddcab60d224c
Source note	uspto-grants-1979_01