Hydrochloric Acid → HCID 22750118, compound

Participants

Reaction Steps

0.49 gm (13.0 millimols) of sodium borohydride were added at 0° C. to a solution of 4.0 gm (8.2 millimols) of 1-[4,4-dimethyl-6,7-dimethoxy-1,3-dioxo-(2H,4H)-isoquinolin-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane in a mixture of 100 ml of dioxane and 20 ml of water. The mixture was stirred at room temperature for 8 hours and subsequently admixed with 100 ml of 2 N hydrochloric acid. After extraction with chloroform, the organic extract was dried over sodium sulfate and evaporated in vacuo, leaving as a residue 3.25 gm (80% of theory) of 1-[3-hydroxy-4,4-dimethyl-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane.

Provenance & Evidence