Ethanol → HCID 12744619, compound

HRID 2164058Notes

Reaction equation

HRID 2164058 reaction equation
P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:7][C:8]1[N:9]2[CH:15]=[C:14]([C:16]([OH:18])=[O:17])[N:13]=[C:10]2[S:11][CH:12]=1.[CH2:19](O)[CH3:20]>C(Cl)Cl.O>[CH3:7][C:8]1[N:9]2[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:13]=[C:10]2[S:11][CH:12]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 24819Phosphorus pentachlorideHCID 5028377HCID 5028377, compound

Product 1

HCID 12744619HCID 12744619, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 6.3 g of phosphorus pentachloride in 120 ml of dry methylene chloride, 5 g of 3-methyl-imidazo-(2,1-b)thiazole-6-carboxylic acid (prepared as described in Example 10) is added and the suspension obtained is refluxed for 3 hours. After vacuum evaporation of the solvent the residue obtained being 3-methyl-imidazo-(2,1-b)thiazole-6-carboxylchloride chlorohydrate is dissolved in 100 ml of abs. ethanol and the solution is refluxed for 4 hours. The solvent is removed and the residue obtained is dissolved in water. The solution obtained is neutralised to pH 7.5 to yield 5 g of 3-methyl-6-carboethoxy-imidazo-(2,1-b)thiazole; m.p. 117°-119°.

Workup

  1. customthe suspension obtained
  2. temperatureis refluxed for 3 hours
  3. customAfter vacuum evaporation of the solvent the residue
  4. customobtained
  5. dissolutionis dissolved in 100 ml of abs
  6. customThe solvent is removed
  7. customthe residue obtained
  8. customThe solution obtained

Sources & evidence

ORD record
ord-490a436a7d054468875099c3748ee1fa
Source dataset
uspto-grants-1979_01
Patent number
US04137320

Reaction notes

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