2-Aminopyridine → HCID 54684964, compound

HRID 2164102Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12]([OH:23])=[C:13]([C:19](OC)=[O:20])[N:14]([CH3:18])[S:15](=[O:17])(=[O:16])[C:5]=3[C:4]=2[CH:3]=1.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12]([OH:23])=[C:13]([C:19]([NH:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)=[O:20])[N:14]([CH3:18])[S:15](=[O:16])(=[O:17])[C:5]=3[C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 104392-Aminopyridine

HCID 54684967HCID 54684967, compound

Product 1

HCID 54684964HCID 54684964, compoundYield 72%

Procedure

8-Chloro-2,5-dihydro-2,5-dimethyl-4-hydroxy-N-(2-pyridyl)-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 18 from methyl 8-chloro-2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate-1,1-dioxide and 2-amino-pyridine with a yield of 72% of theory; M.p.: 245° C. (decomposition).

Sources & evidence

ORD record: ord-072efb19324d4e5c9ff9fef6d1016fb4
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137313

Reaction notes

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