Potassium Permanganate → HCID 22750011, compound

Participants

Reaction Steps

A suspension of 40.8 gm (0.145 mol) of methyl 3-aminosulfinyl-5-methoxy-1-methyl-indole-2-carboxylate in 3 liters of acetone was reacted with 17.4 gm (0.11 mol) of potassiumpermanganate in 350 ml of water and processed analogous to Example 18(c). 33.7 gm (78% of theory) of methyl 5-methoxy-1-methyl-3-sulfamoyl-indole-2-carboxylate, M.p.: 190° C., and 7.4 gm (19% of theory) of 7-methoxy-4-methyl-2H-isothiazolo[4,5-b]indole-3(4H)-one-1,1-dioxide, M.p.: above 290° C. (decomposition), were obtained.

Provenance & Evidence