Methyl iodide → HCID 54684968, compound

HRID 2164108Notes

Reaction equation

HRID 2164108 reaction equation
[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][C:7]([CH3:11])=[CH:6][C:5]=2[C:4]2[S:12](=[O:22])(=[O:21])[NH:13][C:14]([C:17]([O:19][CH3:20])=[O:18])=[C:15]([OH:16])[C:3]1=2.[OH-].[Na+].[CH3:25]I>CO>[OH:16][C:15]1[C:3]2[N:2]([CH3:1])[C:10]3[CH:9]=[CH:8][C:7]([CH3:11])=[CH:6][C:5]=3[C:4]=2[S:12](=[O:22])(=[O:21])[N:13]([CH3:25])[C:14]=1[C:17]([O:19][CH3:20])=[O:18]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 54684948HCID 54684948, compound

Product 1

HCID 54684968HCID 54684968, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.7 gm of methyl 2,5-dihydro-5,8-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate-1,1-dioxide were reacted analogous to Example 18(f) with 5.3 ml of 1 N sodium hydroxide and 2.6 gm of methyl iodide in 20 ml of methanol to yield 1.5 gm (84% of theory) of methyl 2,5-dihydro-4-hydroxy-2,5,8-trimethyl-1,2-thiazino [5,6-b]indole-3-carboxylate-1,1-dioxide; M.p.: 144°-145° C.

Sources & evidence

ORD record
ord-a2eca525578f4a68b1e4f9b47bc921ab
Source dataset
uspto-grants-1979_01
Patent number
US04137313

Reaction notes

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