4-Fluoroaniline → 2,5-Dihydro-2,5-dimethyl-N-(4-fluoro-phenyl)-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoroaniline	HCID 9731	—
Reactant	n-Butyl 2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate-1,1-dioxide	HCID 54684961	—
Solvent	O-Xylene	HCID 7237	—
Product	2,5-Dihydro-2,5-dimethyl-N-(4-fluoro-phenyl)-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide	HCID 54684985	68%

Reaction Steps

2,5-Dihydro-2,5-dimethyl-N-(4-fluoro-phenyl)-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 9 from n-butyl 2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate-1,1-dioxide and 4-fluoro-aniline in xylene; M.p.: 271°-272° C. (decomp.); Yield: 68% of theory;

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04137313
Source dataset	uspto-grants-1979_01
ORD ID	ord-abbb54c8efb74c8b8ccda593ad4447b1
Source note	uspto-grants-1979_01