HCID 86736276, compound → HCID 22750003, compound

Participants

Reaction Steps

2.2 gm (7.4 millimols) of 2,5-dihydro-2,5-dimethyl-1,2-thiazino[5,6-b]-indole-4(3H)-one-1,1-dioxide-ethylene ketal were refluxed for one hour in a mixture of 60 ml of 9% hydrochloric acid and 60 ml of methanol. Subsequently, the mixture was evaporated to dryness in vacuo. After taking up the residue in methylene chloride, washing the solution with water, drying and evaporating it, and recrystallizing the raw product from ethanol, 1.6 gm (82% of theory) of 2,5-dihydro-2,5-dimethyl-1,2-thiazino-[5,6-b]indole-4(3H)-one-1,1-dioxide were obtained; M.p.: 180° C.; 1H-NMR (CDCl3): δ = 8.0 (m, 1) and 7.4 (m, 3; arom. H) 4.15 (s, 2, CH2); 4.06 (s, 3, 5-CH3); 3.00 (s, 3, 2-CH3).

Provenance & Evidence