Hydrochloric Acid → HCID 70604919, compound

Participants

Reaction Conditions

Reaction Steps

7-[α-Methylsulfonyl(2-furyl)acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (366.4 mg), 128 mg of 2-mercapto-5-methyl-1,3,4-thiadiazole and 68 mg of sodium bicarbonate were dissolved in a 0.1N phosphate buffer (pH 6.4), and the solution was stirred at 60° C. for 8 hours. Then, 20 ml of water, and 50 ml of ethyl acetate were added for extraction. The aqueous layer was acidified with 1H hydrochloric acid to a pH of 2, and extracted with ethyl acetate three times. The organic layer was washed four times with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, and concentrated under reduced pressure to obtain the product in powder form.

Provenance & Evidence