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HRID2164143

反应详情

EQUATION

反应方程式

HRID 2164143 的结构方程式

REACTANTS

反应物

4
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

2 次

结构：O
HCID962

Water

H2O

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O
HCID33613

Amoxicillin

C16H19N3O5S

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.O.O.O
HCID62883

Amoxicillin hydrate (1:3)

C16H25N3O8S

PRODUCTS

生成物

1
结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.CS(C)=O
HCID70528119

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Fifty grams of amoxicillin trihydrate is added in portions, with stirring, to 375 ml. of dimethyl sulfoxide. The mixture is stirred at room temperature for 2 hours, then diluted with 75 ml. of methylene chloride and cooled to 0°-5°. The solid product is collected by filtration, washed with methylene chloride and dried. Analysis shows 3 moles of dimethyl sulfoxide and 0.5 mole of water for each mole of amoxicillin; formula weight = 609.

WORKUP

后处理

  1. stirringThe mixture is stirred at room temperature for 2 hours
  2. additiondiluted with 75 ml
  3. filtrationThe solid product is collected by filtration
  4. washwashed with methylene chloride
  5. customdried