Piperidine → 1-[4-(1-Piperidinylsulfonyl)phenyl]ethanone

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Reaction Steps

The damp 4-acetylbenzenesulfonyl chloride from 100 g. of sodium 4-acetylbenzenesulfonate is added to a stirred solution of 500 ml. of 50% aqueous piperidine. The mixture is stirred at room temperature for 16 hours, cooled, and the precipitated 1-(4-acetylbenzenesulfonyl)-piperidine removed by filtration, washed with water and dried; m.p. 113°-114° C. after crystallization from 2-propanol.

Provenance & Evidence