N,N-Dimethylethylenediamine → 4-acetyl-N-(2-dimethylaminoethyl)benzenesulfonamide

Participants

Reaction Steps

The damp 4-acetylbenzenesulfonyl chloride from 100 g. of sodium 4-acetylbenzenesulfonate is added to a solution of 83 g. of N,N-dimethylethylenediamine in 730 ml. of water. The mixture is stirred at room temperature for 16 hours, cooled, and the precipitate of 4-acetyl-N-(2-dimethylaminoethyl)benzenesulfonamide collected by filtration, washed with water and dried; m.p. 87-89° C. after crystallization from 2-propanol/hexane.

Provenance & Evidence