HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → Cyanoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-Acetyl-N-(2-hydroxyethyl)benzenesulfonamide | HCID 22750307 | — |
| Reactant | 4-[(2-Hydroxyethyl)aminosulfonyl]benzoylacetaldehyde | HCID 53894223 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Cyanoacetamide | HCID 7898 | — |
| Product | 3-Cyano-2-pyridone | HCID 577543 | — |
Reaction Steps
From a solution of the sodium salt of 4-[(2-hydroxyethyl)aminosulfonyl]benzoylacetaldehyde in 500 ml. of water (prepared from 41.3 g. of sodium methoxide in 400 ml. of tetrahydrofuran, 56.6 g. of ethyl formate, and a solution of 56.5 g. of 4-acetyl-N-(2-hydroxyethyl)-benzenesulfonamide in 700 ml. of tetrahydrofuran) and 29.7 g. of cyanoacetamide, there is obtained 6-[4-[2-hydroxyethyl)aminosulfonyl]phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 283°-286° C. after crystallization from methanol-dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04137408 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-9ee2ec9171784631bedca90cac5d0d69 |
| Source note | uspto-grants-1979_01 |