Pyridine → HCID 13455395, compound

HRID 2164197Notes

Reaction equation

HRID 2164197 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl-:1].[Cl-:1].[N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([N+:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:11][C:2]=1[N+:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 1049PyridineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 13455395HCID 13455395, compound

Procedure

A 20-g portion of 2,4-dichloroquinazoline was added to 200 ml of pyridine. The reaction mixture was stirred 11/2 hours, refluxed 11/2 hours, and then allowed to stir under a calcium sulfate drying tube for 3 days. The reaction mixture was filtered. The resulting solid rinsed well with pyridine, then ether, and was dried in vacuo giving 35.9 g of 1,1'-(2,4-quinazolinediyl)bis[pyridinium] dichloride (m.p. 150°-164° ).

Workup

  1. temperaturerefluxed 11/2 hours
  2. stirringto stir under a calcium sulfate drying tube for 3 days
  3. filtrationThe reaction mixture was filtered
  4. washThe resulting solid rinsed well with pyridine
  5. dry with materialether, and was dried in vacuo

Sources & evidence

ORD record
ord-4c127ed9d8294214adcebae6124360e2
Source dataset
uspto-grants-1985_03
Patent number
US04502880

Reaction notes

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