HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → octahydro-3-oxo-1H-isoindole-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-oxo-2,3-dihydro-1H-isoindole-1-carboxylic acid | HCID 9794017 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | octahydro-3-oxo-1H-isoindole-1-carboxylic acid | HCID 13388635 | — |
Reaction Steps
The intermediate octahydro-3-oxo-1H-isoindole-1-carboxylic acid is prepared as follows. 2,3-Dihydro-3-oxo-1H-isoindole-1-carboxylic acid (J. Prakt. Chem., 146, 307(1936)), 20 g is heated at reflux for 2 hours with 250 ml of absolute ethanol and 5.6 g of concentrated sulfuric acid. On cooling, the solution deposits crystalline ethyl 2,3-dihydro-3-oxo-1H-isoindole-3-carboxylate. Recrystallization of this from ethanol gives pure material, mp 178°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04503043 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-85603dea77a546838d4bf959cc06563e |
| Source note | uspto-grants-1985_03 |