Thionyl Chloride → HCID 53768656, compound

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Reaction Steps

3.22 g of 6-chloro-5-cyclopentylmethyl-1-indanecarboxylic acid is heated under reflux for one hour with 10.5 ml of thionyl chloride and concentrated, thus yielding 3.45 g of 6-chloro-5-cyclopentylmethyl-1-indanecarboxylic acid chloride as an oil. The acid chloride is reacted with triethyl phosphite as described in Example 2, yielding 3 g of (6-chloro-5-cyclopentylmethyl-1-indanylidene)hydroxymethanephosphonic acid diethyl ester, mp 126° C. The resultant compound is reacted with diethyl phosphite under the conditions mentioned in Example 2, thus obtaining the (6-chloro-5-cyclopentylmethyl-1-indanyl)hydroxymethane-bis(phosphonic acid diethyl ester).

Provenance & Evidence