Triethyl phosphite → HCID 178476981, compound

Participants

Reaction Steps

A solution of 17.5 g of 4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazoleacetic acid chloride in 100 ml of tetrahydrofuran is cooled to 10° C. and combined with 9.8 ml of triethyl phosphite. The mixture is stirred for 3 hours at 10°-15° C., the solution is concentrated under vacuum, and the oily residue is crystallized from diisopropyl ether, thus obtaining 18.8 g (83.4%) of 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]-1-hydroxyethenephosphonic acid diethyl ester, mp 96°-98° C.

Provenance & Evidence