4-[3-(amino)propoxy]-N,N-dimethyl-2-thiophenemethanamine → 1-Amino-2-[3-(5-dimethylaminomethyl-3-thienyloxy)propylamino]cyclobutene-3,4-dione

HRID 2164250Notes

Reaction equation

HRID 2164250 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:11][N:12]([CH3:14])[CH3:13])[S:9][CH:10]=1.[NH2:15][C:16]1[C:19](=[O:20])[C:18](=[O:21])[C:17]=1OC>>[NH2:15][C:16]1[C:19](=[O:20])[C:18](=[O:21])[C:17]=1[NH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:11][N:12]([CH3:13])[CH3:14])[S:9][CH:10]=1

Participants

3

Reactant 2

HCID 129265244-[3-(amino)propoxy]-N,N-dimethyl-2-thiophenemethanamineHCID 134522053-Amino-4-methoxycyclobut-3-ene-1,2-dione

Product 1

HCID 212830441-Amino-2-[3-(5-dimethylaminomethyl-3-thienyloxy)propylamino]cyclobutene-3,4-dione

Procedure

An equimolar mixture of 4-[3-(amino)propoxy]-N,N-dimethyl-2-thiophenemethanamine [prepared according to the procedure described in published European Patent Application 27,744] and 1-amino-2-methoxycyclobutene-3,4-dione is reacted according to the general procedure of Example 19 to yield the title compound.

Workup

  1. customprepared
  2. customis reacted

Sources & evidence

ORD record
ord-2d22853405cc4f1fa9191c394330acf6
Source dataset
uspto-grants-1985_03
Patent number
US04503051

Reaction notes

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