Morpholine → HCID 8434533, compound

HRID 2164255Notes

Reaction equation

HRID 2164255 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>CO>[OH:17][C:14]1[CH:15]=[CH:16][C:11]([N:8]2[CH2:9][CH2:10][N:5]([C:3](=[O:4])[CH2:2][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH2:6][CH2:7]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 7064021HCID 7064021, compound

Product 1

HCID 8434533HCID 8434533, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 10 parts of 1-(2-chloroacetyl)-4-(4-hydroxyphenyl)piperazine, 6.9 parts of morpholine and 40 parts of methanol is stirred and heated for 2 hours at 50° C. The reaction mixture is evaporated and the residue is stirred with water. The precipitated product is filtered off, dried on the filter and crystallized from 2-propanol, yielding 5.5 parts of 1-(4-hydroxyphenyl)-4-[(4-morpholinyl)acetyl]piperazine; mp. 197.3° C.

Workup

  1. customThe reaction mixture is evaporated
  2. stirringthe residue is stirred with water
  3. filtrationThe precipitated product is filtered off
  4. customdried on the
  5. filtrationfilter
  6. customcrystallized from 2-propanol

Sources & evidence

ORD record
ord-c1ae9c3bf26047a4a1cc0c24c349578b
Source dataset
uspto-grants-1985_03
Patent number
US04503055

Reaction notes

Loading…