Bromine → HCID 13394248, compound

Participants

Reaction Steps

A suspension of 4,5-bis(4-fluorophenyl)-1H-imidazole (25.6 g, 0.1 mol) in chloroform (100 ml) was cooled in an ice bath and treated dropwise with bromine (16.0 g, 0.1 mol) in 50 ml of chloroform. The mixture was stirred in the ice bath for one hour and then at room temperature until no starting material was evidenced by tlc (toluene-ethyl acetate, 6:4). The reaction mixture was filtered and the resulting solid was washed with diethyl ether and dried in vacuo to yield 37.4 g (90%) of the title compound, m.p. 270°-272°.

Provenance & Evidence