HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 1,2-Dihydro-6-methyl-2-oxo-5-[4-(4-phenyl-1-piperidinyl)phenyl]-3-pyridinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine, acetate | HCID 9793820 | — |
| Reactant | 4-(Dimethylamino)-3-[4-(4-phenyl-1-piperidinyl)phenyl]-3-buten-2-one | HCID 53902880 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1,2-Dihydro-6-methyl-2-oxo-5-[4-(4-phenyl-1-piperidinyl)phenyl]-3-pyridinecarboxamide | HCID 13394242 | — |
Reaction Steps
A mixture of 2.6 g of 4-(dimethylamino)-3-[4-(4-phenyl-1-piperidinyl)phenyl]-3-buten-2-one, a mixture of 0.75 g of cyanoacetamide, 0.8 ml of piperidine acetate in 25 ml of acetonitrile is refluxed for 24 hours. The solid is collected, washed with CH3CN7 ether, and dried to give 0.80 g beige solid, mp 335°-338° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04503061 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-465f1fda971342e0824b6662cc3dcd68 |
| Source note | uspto-grants-1985_03 |