Ammonia → 5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2(1H)-pyridinone

Participants

Reaction Steps

A solution of 1,2-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3-pyridinecarbonitrile 21.8 g) in 110 ml of 85% (w/w) sulfuric acid is heated at 205° C. for 19 hours. The reaction mixture is cooled to room temperature, poured into 600 ml of ice, and the resulting solution adjusted to pH 8 with concentrated ammonia. The precipitate is collected and recrystallized from dimethylformamide to give 10.0 g of 5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2(1H)-pyridinone, mp 310°-314° C.

Provenance & Evidence