Hydrochloric Acid → HCID 12901224, compound

Participants

Reaction Steps

A mixture of 40.0 g (0.133 mole) of 7-(4-fluorobenzoyl)-3-methylthioindolin-2-one and 40.0 g (0.34 mole) of tin powder in one liter of 95% ethanol was heated to reflux and 100 ml of concentrated hydrochloric acid was added. The mixture was heated for 6 hrs, then filtered while hot. The filtrate was cooled and the precipitate was collected and recrystallized from isopropyl alcohol to yield 24.5 g (72%) as off-white needles, m.p. 185°-187.0° C.

Provenance & Evidence