HCID 13394284, compound → HCID 13394287, compound

Participants

Reaction Steps

A slurry of 30.5 g (0.091 mol) of 5-chloro-7-(4-fluorobenzoyl)-3-methylthioindolin-2-one in 2.5 l of tetrahydrofuran was stirred vigorously and treated with 285 g of wet Raney nickel for 6 minutes. The mixture was filtered and the filter cake obtained was washed with 200 ml of tetrahydrofuran. The resulting filtrate was evaporated to leave 20.2 g of residue. This residue was recrystallized from acetone to give 16.8 g (64%) of the titled compound as white, fluffy needles, mp. 222°-225° C.

Provenance & Evidence