HCID 20406198, compound → HCID 13394303, compound

Participants

Reaction Steps

A mixture of 60.0 (0.167 mole) of 2-amino-3-(4-fluorobenzoyl)-5-methyl-α-(propylthio)phenylacetamide in 2.4 liters of tetrahydrofuran was treated with 400 g of wet Raney nickel (washed with water and titrated to constant pH 7 with acetic acid, washed again with water and then washed 3 times with tetrahydrofuran). The mixture was filtered and the filtrate was concentrated. The residue was triturated with hot isopropyl ether and recrystallized from isopropyl alcohol to give 43.6 (91%) of the titled compound as bright yellow crystals, m.p. 203°-206° C.

Provenance & Evidence