N,N,N',N',N'',N''-Hexamethylmethanetriamine → HCID 53984045, compound

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Reaction Steps

By following the procedure of Example 3, but replacing the bis-dimethylamino-t-butoxymethane by trisdimethylaminomethane (1.75 cc) and starting from 7-dimethoxyphosphorylamino-3-methyl-2-(4-nitrobenzyloxycarbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (2.3 g), 7-dimethoxyphosphorylamino-3-(2-dimethylaminovinyl)-2-(4-nitrobenzyloxycarbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (E isomer) (1.5 g) is obtained in the form of an orange crystalline powder, m.p.=236°-237° C. An analytically pure sample is obtained by recrystallisation from acetonitrile: yellow crystals, m.p.=252°-253° C.

Provenance & Evidence