反应详情

A mixture of 469 g (2.02 moles) farnesyl cyanide, 287 g potassium hydroxide, 2,500 ml ethanol and 340 ml water were heated under reflux. After 5 hours, the ethanol was evaporated and the residue poured into 10 liters of water. The aqueous solution so obtained was twice extracted with 1 liter diethyl ether, the extracts being discarded, and thereafter acidified with 20% sulfuric acid. Then, the free acid was extracted with diethyl ether. The etheric solution was again washed with water and dried with sodium sulfate. After evaporation of the ether, 419 g (83% of the theoretical) of homofarnesic acid were obtained as a yellow oil.

1. temperaturewere heated
2. temperatureunder reflux
3. customthe ethanol was evaporated
4. additionthe residue poured into 10 liters of water
5. customThe aqueous solution so obtained
6. extractionwas twice extracted with 1 liter diethyl ether
7. extractionThen, the free acid was extracted with diethyl ether
8. washThe etheric solution was again washed with water
9. dry with materialdried with sodium sulfate
10. customAfter evaporation of the ether, 419 g (83% of the theoretical) of homofarnesic acid
11. customwere obtained as a yellow oil