Hydroxylamine, O-ethyl- → HCID 136196406, compound

HRID 2164369Notes

Reaction equation

HRID 2164369 reaction equation
[OH:1][C:2]1[CH2:7][CH:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=2)[CH2:5][C:4](=[O:18])[C:3]=1[C:19](=O)[CH2:20][CH3:21].[CH2:23]([O:25][NH2:26])[CH3:24]>CO>[CH2:23]([O:25][N:26]=[C:19]([C:3]1[C:4](=[O:18])[CH2:5][CH:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=2)[CH2:7][C:2]=1[OH:1])[CH2:20][CH3:21])[CH3:24]

Participants

4

Reactant 2

HCID 69357Hydroxylamine, O-ethyl-HCID 178458864HCID 178458864, compound

Product 1

HCID 136196406HCID 136196406, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into 20 ml of methanol was dissolved 2.5 g of 3-hydroxy-5-(4-methoxycarbonylphenyl)-2-propionyl-2-cyclohexen-1-one and to the solution was added 0.7 g of ethoxyamine. The mixture was kept for 15 hours at room temperature and it was poured into ice water. The crystal sedimented was collected with a filtering step and recrystallized with mixture solvent of methanol-water. Thus, 1.9 g of the desired compound which was in the form of colorless crystals having a melting point of 75°-76° C. was obtained.

Workup

  1. customThe crystal sedimented was collected with a filtering step
  2. customrecrystallized with mixture solvent of methanol-water
  3. customwas obtained

Sources & evidence

ORD record
ord-21973af7b0554d83b28b4f91db4f3587
Source dataset
uspto-grants-1985_03
Patent number
US04504305

Reaction notes

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