Butyl nitrite → HCID 13175418, compound

Participants

Reaction Steps

A diazonium salt is formed by reacting 2-chloro-5-amino- 6-phenoxypyridine with butyl nitrite in the presence of HPF6 and is decomposed by heating (Baltz-Schiemann reaction) to obtain 2-chloro-5-fluoro-6-phenoxypyridine. The obtained product is reacted with magnesium and then with a formylating agent such as dimethylformamide to obtain 5-fluoro-6-phenoxy picolinic aldehyde. In the case where cyano(5-fluoro-6-phenoxy-2-pyridyl) methyl alcohol is required, it is prepared by reacting the aldehyde with sodiumbisulfite and then with a cyanide compound such as sodium cyanide.

Provenance & Evidence