反应详情

17.5 g of 2-(3-acetylureido)-5-phenoxysulfonylaniline and 15 ml of methoxycarbonyl isothiocyanate in 150 ml of dioxane are heated at 80° C. for 5 minutes, and then stirring is continued without heating. After slowly cooling down to room temperature, the dioxane is distilled out under reduced pressure. The residue is dissolved in dimethylformamide, the solution is treated with active charcoal and evaporated and then methanol is added. After cooling down, the precipitate is filtered off with suction and washed with methanol and diisopropyl ether. Melting point 215° C., decomposition.

1. temperaturewithout heating
2. distillationthe dioxane is distilled out under reduced pressure
3. dissolutionThe residue is dissolved in dimethylformamide
4. additionthe solution is treated with active charcoal
5. customevaporated
6. additionmethanol is added
7. temperatureAfter cooling down
8. filtrationthe precipitate is filtered off with suction
9. washwashed with methanol and diisopropyl ether