Chlorosulfonyl isocyanate → HCID 20405591, compound

Participants

Reaction Steps

30 ml of N-chlorosulfonyl isocyanate dissolved in 70 ml of toluene are rapidly added dropwise, at +10° C., to 88.2 g of 2-amino-5-phenoxysulfonylnitrobenzene in 750 ml of toluene. The mixture is stirred for a further hour while cooling, and the precipitate is filtered off with suction, washed with diisopropyl ether and dried in a desiccator over potassium hydroxide. 88 g of the 2-(3-chlorosulfonylureido)-5-phenoxysulfonylnitrobenzene produced are introduced, with stirring and cooling, into 800 ml of 1N HCl. After 30 minutes, the clear solution is briefly warmed to 80° C. (precipitation) and then left to stand. After cooling down, the solid is filtered off with suction and washed with water to neutrality, melting point 190° C.

Provenance & Evidence