HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 178502525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate | HCID 98708 | — |
| Reactant | 2-(3-Acetylureido)-5-(3-trifluoromethylphenylsulfonyloxy)aniline | HCID 15585469 | — |
| Product | HCID 178502525 | HCID 178502525 | — |
Reaction Steps
14.6 g of 2-(3-acetylureido)-5-(3-trifluoromethylphenylsulfonyloxy)aniline, 12.4 g of N,N'-bismethoxycarbonyl-S-methylisothiourea and 75 mg of p-toluenesulfonic acid are stirred under reflux for two hours. After cooling down, the mixture is evaporated under reduced pressure, the residue is recrystallized from isopropanol and the crystals are stirred with cold ethyl acetate, filtered off with suction and washed, melting point 189° C., decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04504490 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-696cca6d470e43d4b52233793f0e00df |
| Source note | uspto-grants-1985_03 |