Chlorosulfonyl isocyanate → HCID 20405594, compound

Participants

Reaction Steps

30 ml of N-chlorosulfonyl isocyanate are added dropwise, at +10° C., to 108 g of 2-amino-5-(3-trifluoromethylphenylsulfonyloxy)nitrobenzene in 800 ml of toluene. The mixture is stirred for a further two hours while cooling, and 500 ml of petroleum ether are added. The 2-(3-chlorosulfonylureido)-5-(3-trifluoromethylphenylsulfonyloxy)nitrobenzene produced is filtered off with suction, washed with petroleum ether and dried over potassium hydroxide, melting point 137° C., decomposition. 150 g of this sulfochloride are introduced, with stirring and cooling in ice, into 2 liters of 1N HCl. The mixture is stirred for 2 hours while cooling and for 5 hours at room temperature, and next day the precipitate is filtered off with suction, washed with water to neutrality and dried, melting point 152° C.

Provenance & Evidence