2-(3-Acetylureido)-5-(3-trifluoromethylphenylsulfonyloxy)nitrobenzene → 2-(3-Acetylureido)-5-(3-trifluoromethylphenylsulfonyloxy)aniline

Participants

Reaction Steps

59 g of 2-(3-acetylureido)-5-(3-trifluoromethylphenylsulfonyloxy)nitrobenzene in 200 ml of methanol and 200 ml of 2-methoxyethanol are hydrogenated under normal pressure with a catalytic amount of Raney nickel. After hydrogen uptake is complete, the catalyst is filtered off with suction, washed with warm 2-methoxyethanol and the solution is evaporated under reduced pressure. Water is added to the residue and it is then filtered off with suction, washed with water and dried over sodium hydroxide, melting point 182° C.

Provenance & Evidence