참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 2-Benzoylbenzaldehyde | HCID 161195 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | HCID 13195968 | HCID 13195968 | — |
| 촉매 | Pyridine | HCID 1049 | — |
| 촉매 | (Trimethylsilyl)methyl Trifluoromethanesulfonate [Trimethylsilylmethylating Reagent] | HCID 2760857 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(1,3-Dioxolan-2-YL)benzophenone | HCID 10515088 | — |
반응 단계
To a stirred solution of benzoylbenzaldehyde (2 g, 10 mmol) and 1,2-bis-(trimethoxysiloxy)ethane (2.3 g, 11 mmol) in dry dichloromethane (30 cm3) under N2 at room temperature was added trimethylsilylmethyl trifluoromethanesulphonate (5 drops). After stirring at 20° C. for 48 hours, pyridine (3 drops) was added followed by saturated NaHCO3 (20 cm3) and diethyl ether (20 cm3). The resulting mixture was stirred for 30 minutes. The ethereal layer was separated off and the aqueous layer extracted twice more with diethyl ether. The combined extracts were washed with water, dried over a mixture of anhydrous Na2CO3 and anhydrous Na2SO4 (1:1) and the solvent removed in vacuo to give 2-(3-benzoylphenyl)-1,3-dioxolane, nD20 1.5890. Yield 2.2 g (91.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04504491 |
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| 출처 데이터셋 | uspto-grants-1985_03 |
|---|
| ORD ID | ord-2ae659d81b1c46e0943d7a38d3145739 |
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| 출처 메모 | uspto-grants-1985_03 |
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