Sulfuric Acid → HCID 13102754, compound

Participants

Reaction Conditions

Reaction Steps

To methyl magnesium iodide (1.4 g) in ether (25 cm3) was added a solution of α-ethynyl-3-benzoylbenzyl alcohol (0.5 g) in ether (10 cm3) with stirring during 10 minutes at 20° C., then the mixture refluxed for 5 minutes and poured onto a mixture of 40% sulphuric acid (40 cm3), sodium thiosulphate (3 g) and tetrahydrofuran (20 cm3). After 16 hours at 20° C., this mixture was extracted with ether (3×150 cm3), washed with sodium thiosulphate solution (2M), saturated sodium chloride, dried and finally evaporated to give the title product, yield 0.48 g (96%) nD20 1.5942.

Provenance & Evidence