2-Chloronicotinic acid → 2-Chloro-3-(trichloromethyl)pyridine

HRID 2164454Notes

Reaction equation

HRID 2164454 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=O.ClC1C(C(F)(F)F)=CC=CN=1.[Cl-:22].[Al+3].[Cl-:24].[Cl-:25]>>[Cl:1][C:2]1[C:3]([C:4]([Cl:25])([Cl:24])[Cl:22])=[CH:7][CH:8]=[CH:9][N:10]=1

Participants

4

Reactant 3

HCID 762582-Chloronicotinic acidHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 6451240Aluminum(III) Chloride

Product 1

HCID 6066982-Chloro-3-(trichloromethyl)pyridine

Procedure

The process according to claim 4 wherein 2-chloronicotinic acid is produced by reacting 2-chloro-3-trifluoromethyl pyridine with aluminum chloride to obtain 2-chloro-3-trichloromethyl pyridine and then hydrolyzing the 2-chloro-3-trichloromethyl pyridine in the presence of sulfuric acid or phosphoric acid.

Workup

  1. customis produced

Sources & evidence

ORD record
ord-f34ae5676ea5471cb14ee6c9600fb57c
Source dataset
uspto-grants-1985_03
Patent number
US04504665

Reaction notes

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