4-(Aminosulfonyl)-5-chlorophthalimide → Phthalimide

Participants

Reaction Steps

6-Chloro-2,3-dihydro-1,3-dioxo-2-(3-pyridinylmethyl)-1H-isoindole-5-sulfonamide. Reaction of a mixture of 4-chloro-5-sulfamoylphthalimide and 3-(aminomethyl)pyridine according to the procedure of Example 1(a) afforded a 73% yield of the 1,3-dioxoisoindole intermediate. Crystallization of this material from dimethylformamide-methanol provided analytically pure 6-chloro-2,3-dihydro-1,3-dioxo-2-(3-pyridinylmethyl)-1H-isoindole-5-sulfonamide, m.p. 210°-212°.

Provenance & Evidence