4-(Aminosulfonyl)-5-chlorophthalimide → Phthalimide

Participants

Reaction Steps

6-Chloro-2,3-dihydro-1,3-dioxo-2-[2-(2-pyridinyl)ethyl]-1H-isoindole-5-sulfonamide. Reaction of a mixture of 4-chloro-5-sulfamoylphthalimide and 2-(2-aminoethyl)pyridine according to the procedure of Example 1(a) afforded 81% yield of the 1,3-dioxoisoindole intermediate. Crystallization of this material from dimethylformamidemethanol provided analytically pure 6-chloro-2,3-dihydro-1,3-dioxo-2-[2-(2-pyridinyl)ethyl]-1H-isoindole-5-sulfonamide, m.p. 240°-241°.

Provenance & Evidence