4-(Aminosulfonyl)-5-chlorophthalimide → Phthalimide

Participants

Reaction Steps

6-Chloro-2,3-dihydro-1,3-dioxo-2-[2-(4-pyridinyl)ethyl]-1H-isoindole-5-sulfonamide. Reaction of a mixture of 4-chloro-5-sulfamoylphthalimide and 4-(2-aminoethyl)pyridine according to the procedure of Example 1(a) afforded a 93% yield of the 1,3-dioxoisoindole intermediate. Crystallization of this material from dimethylformamide provided analytically pure 6-chloro-2,3-dihydro-1,3-dioxo-2-[2-(4-pyridinyl)ethyl]-1H-isoindole-5-sulfonamide, m.p. 277°-278° (dec.).

Provenance & Evidence