N,N-Dimethyl-1,3-propanediamine → Phthalimide

Participants

Reaction Steps

6-Chloro-2-[3-(dimethylamino)propyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide. Reaction of a mixture 4-chloro-5-sulfamoylphthalimide and 3-(dimethylamino)propylamine according to the procedure of Example 1(a) afforded a 95% yield of the 1,3-dioxoisoindole intermediate. Crystallization of this material from dimethylformamide-ethanol provided analytically pure 6-chloro-2-[3-(dimethylamino)propyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide, m.p. 192°-194°.

Provenance & Evidence