Benzoic acid, 2-chloro-5-(chlorosulfonyl)- → HCID 13705954, compound

HRID 2164556Notes

Reaction equation

HRID 2164556 reaction equation
[CH3:1][CH:2]([CH3:20])[CH2:3][NH:4][S:5]([C:8]1[CH:19]=[C:12]2[C:13]([O:15]C(=O)[NH:17][C:11]2=[CH:10][CH:9]=1)=[O:14])(=[O:7])=[O:6].[Cl:21]C1C=CC(S(Cl)(=O)=O)=CC=1C(O)=O>>[Cl:21][C:11]1[CH:10]=[CH:9][C:8]([S:5](=[O:7])(=[O:6])[NH:4][CH2:3][CH:2]([CH3:20])[CH3:1])=[CH:19][C:12]=1[C:13]([OH:15])=[O:14].[CH3:1][CH:2]([CH3:20])[CH2:3][NH:4][S:5]([C:8]1[CH:19]=[C:12]([C:13]([OH:15])=[O:14])[C:11]([NH2:17])=[CH:10][CH:9]=1)(=[O:7])=[O:6]

Participants

4

Reactant 2

HCID 67306Benzoic acid, 2-chloro-5-(chlorosulfonyl)-HCID 54563094HCID 54563094, compound

Product 2

HCID 13705954HCID 13705954, compoundHCID 20404888HCID 20404888, compound

Procedure

5-[N-(2-Methylpropyl)-sulfamoyl]-isatoic anhydride, which is to be used as the starting material, can be obtained, for example, in a manner analogous to that described in Example 1, using 2-chloro-5-chlorosulfonylbenzoic acid as the starting material, the product being obtained via 2-chloro-5-[N-(2-methylpropyl)-sulfamoyl]-benzoic acid with a melting point of 163°-166° and 5-[N-(2-methylpropyl)-sulfamoyl]-anthranilic acid with a melting point of 203°-205°; the product melts at 270°-273°.

Sources & evidence

ORD record
ord-0cb27adb54c34d699bb0b57f2009d384
Source dataset
uspto-grants-1985_03
Patent number
US04505913

Reaction notes

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