Hydrochloric Acid → HCID 86739452, compound

Participants

Reaction Conditions

Reaction Steps

4-Allyloxy-3-chloro-phenylacetyl-(DL)-alanine methyl ester (2.0 g) was suspended in acetone (20 ml). Aqueous sodium hydroxide (1M, 8.0 ml) was added and the mixture was gently warmed to effect solution, and then heated at 40° C. for 20 min. After the solution has been cooled, the pH was adjusted to 2-3 using dilute hydrochloric acid (3M) and the product was extracted with ethyl acetate (40 ml). The extract was dried (anhydrous sodium sulphate). The solvent was evaporated at reduced pressure to leave a solid residue (1.8 g); it had m.p. 120°-124° C. After recrystallisation from ethyl acetate/light petroleum (b.p. 60°-80° C.) the above-named product, (1.6 g), m.p. 123°-124° C. was obtained.

Provenance & Evidence